OAS2

OAS2
Identifiers
Aliases	OAS2, 2'-5'-oligoadenylate synthetase 2
External IDs	OMIM: 603350; MGI: 2180852; HomoloGene: 49478; GeneCards: OAS2; OMA:OAS2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	113,011,723 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	120,887,918 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; lymph node; ; decidua; ; appendix; ; gallbladder; ; spleen; ; right lung; ; blood; ; olfactory zone of nasal mucosa;
	Top expressed in
	mucous cell of stomach; ; granulocyte; ; stroma of bone marrow; ; submandibular gland; ; epithelium of stomach; ; blood; ; gastrula; ; myocardium of ventricle; ; subcutaneous adipose tissue; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleotidyltransferase activity; zinc ion binding; metal ion binding; 2'-5'-oligoadenylate synthetase activity; protein binding; RNA binding; double-stranded RNA binding; ATP binding;
Cellular component	cytoplasm; membrane; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; nucleus; nucleoplasm; cytosol; intracellular membrane-bounded organelle;
Biological process	purine nucleotide biosynthetic process; interferon-gamma-mediated signaling pathway; immune system process; protein myristoylation; response to virus; RNA catabolic process; protein glycosylation; defense response to virus; type I interferon signaling pathway; immune response; innate immune response; nucleobase-containing compound metabolic process; response to bacterium; regulation of ribonuclease activity; regulation of lactation;
	Sources:Amigo / QuickGO
Orthologs
	4939
	246728
	ENSG00000111335
	ENSMUSG00000032690
	P29728
	E9Q9A9
	NM_001032731; NM_002535; NM_016817
	NM_145227; NM_001347448
	NP_001027903; NP_002526; NP_058197
	NP_001334377; NP_660262
	Wikidata
View/Edit Human	View/Edit Mouse

2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene.

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.