OAS3

OAS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4S3N
Identifiers
Aliases	OAS3, p100, p100OAS, 2'-5'-oligoadenylate synthetase 3
External IDs	OMIM: 603351; MGI: 2180850; HomoloGene: 4510; GeneCards: OAS3; OMA:OAS3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	112,976,460 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	120,915,726 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; decidua; ; gallbladder; ; apex of heart; ; mucosa of esophagus; ; appendix; ; bone marrow cells; ; oral cavity; ; epithelium of colon;
	Top expressed in
	granulocyte; ; blood; ; mucous cell of stomach; ; intestinal villus; ; jejunum; ; bone marrow; ; stroma of bone marrow; ; zygote; ; thymus; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleotidyltransferase activity; metal ion binding; 2'-5'-oligoadenylate synthetase activity; protein binding; RNA binding; double-stranded RNA binding; ATP binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; plasma membrane; nucleoplasm; nucleus; extracellular space; cytosol;
Biological process	regulation of ribonuclease activity; immune system process; interferon-gamma-mediated signaling pathway; response to virus; negative regulation of viral genome replication; defense response to virus; type I interferon signaling pathway; immune response; innate immune response; nucleobase-containing compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4940
	246727
	ENSG00000111331
	ENSMUSG00000032661
	Q9Y6K5
	Q8VI93
	NM_006187
	NM_145226
	NP_006178
	NP_660261
	Wikidata
View/Edit Human	View/Edit Mouse

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligomers activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.