OAZ1

OAZ1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZGY, 4ZGZ, 5BWA
Identifiers
Aliases	OAZ1, AZI, OAZ, ornithine decarboxylase antizyme 1, AZ1
External IDs	OMIM: 601579; MGI: 109433; HomoloGene: 7455; GeneCards: OAZ1; OMA:OAZ1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	2,273,490 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,665,124 bp
RNA expression pattern
	Top expressed in
	Pons; ; blood; ; pylorus; ; pars compacta; ; renal medulla; ; superior vestibular nucleus; ; monocyte; ; cardia; ; postcentral gyrus; ; parotid gland;
	Top expressed in
	bone marrow; ; neural layer of retina; ; secondary oocyte; ; proximal tubule; ; zygote; ; right kidney; ; Mesencephalon; ; quadriceps femoris muscle; ; neural tube; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ornithine decarboxylase inhibitor activity; protein binding;
Cellular component	cytosol; nucleus; cytoplasm;
Biological process	positive regulation of intracellular protein transport; polyamine biosynthetic process; negative regulation of polyamine transmembrane transport; negative regulation of catalytic activity; regulation of cellular amino acid metabolic process; positive regulation of protein catabolic process; polyamine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4946
	18245
	ENSG00000104904
	ENSMUSG00000035242
	P54368
	P54369
	NM_004152; NM_001301020
	NM_001301034; NM_008753
	NP_001287949; NP_004143
	NP_001287963; NP_032779
	Wikidata
View/Edit Human	View/Edit Mouse

Ornithine decarboxylase antizyme is an enzyme that in humans is encoded by the OAZ1 gene.

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation.