ODF2

ODF2
Identifiers
Aliases	ODF2, CT134, ODF2/1, ODF2/2, ODF84, outer dense fiber of sperm tails 2
External IDs	OMIM: 602015; MGI: 1098824; HomoloGene: 1907; GeneCards: ODF2; OMA:ODF2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,501,292 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	29,821,758 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; right hemisphere of cerebellum; ; right uterine tube; ; anterior pituitary; ; stromal cell of endometrium; ; ventricular zone; ; sural nerve; ; tendon of biceps brachii;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; tail of embryo; ; zygote; ; secondary oocyte; ; primitive streak; ; cerebellar cortex; ; renal corpuscle; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; protein binding;
Cellular component	cytoplasm; ciliary basal body; cytosol; cell projection; spindle pole; outer dense fiber; ciliary transition fiber; microtubule organizing center; centriole; microtubule; cytoskeleton; nucleus; centrosome; cilium; motile cilium; sperm flagellum; centriolar subdistal appendage;
Biological process	cell differentiation; multicellular organism development; G2/M transition of mitotic cell cycle; spermatogenesis; spermatid development; regulation of cilium assembly; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; protein localization; centriole-centriole cohesion; cilium organization;
	Sources:Amigo / QuickGO
Orthologs
	4957
	18286
	ENSG00000136811
	ENSMUSG00000026790
	Q5BJF6
	A3KGV1
NM_001242352; NM_001242353; NM_001242354; NM_002540; NM_153432;
	NM_153433; NM_153435; NM_153436; NM_153437; NM_153439; NM_153440; NM_001351577; NM_001351578; NM_001351579; NM_001351580; NM_001351581; NM_001351582; NM_001351583; NM_001351584; NM_001351585; NM_001351586; NM_001351587; NM_001351588
NM_001113213; NM_001113214; NM_001177659; NM_001177661; NM_013615;
	NM_001355136; NM_001355137; NM_001355138; NM_001369060; NM_001374179; NM_001374180; NM_001374181; NM_001374182
NP_001229281; NP_001229282; NP_001229283; NP_002531; NP_702910;
	NP_702911; NP_702913; NP_702914; NP_702915; NP_702917; NP_702918; NP_001338506; NP_001338507; NP_001338508; NP_001338509; NP_001338510; NP_001338511; NP_001338512; NP_001338513; NP_001338514; NP_001338515; NP_001338516; NP_001338517
NP_001106684; NP_001106685; NP_001171130; NP_001171132; NP_038643;
	NP_001342065; NP_001342066; NP_001342067; NP_001355989; NP_001361108; NP_001361109; NP_001361110; NP_001361111
	Wikidata
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Outer dense fiber protein 2, also known as cenexin, is a protein that in humans is encoded by the ODF2 gene.

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of this gene; however, not all isoforms and variants have been fully described.