OGDH

OGDH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ERY
Identifiers
Aliases	OGDH, AKGDH, E1k, OGDC, oxoglutarate dehydrogenase, KGD1, OGDH2, OGDHD
External IDs	OMIM: 613022; MGI: 1098267; HomoloGene: 55662; GeneCards: OGDH; OMA:OGDH - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,709,066 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,306,642 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; muscle of thigh; ; left ventricle; ; right auricle of heart; ; triceps brachii muscle; ; myocardium of left ventricle; ; glutes; ; Skeletal muscle tissue of rectus abdominis; ; right adrenal gland;
	Top expressed in
	myocardium of ventricle; ; cardiac muscle tissue of left ventricle; ; right ventricle; ; muscle of thigh; ; brown adipose tissue; ; plantaris muscle; ; extensor digitorum longus muscle; ; epithelium of stomach; ; digastric muscle; ; soleus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxoglutarate dehydrogenase (NAD+) activity; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding; heat shock protein binding; chaperone binding;
Cellular component	cytosol; mitochondrial membranes; mitochondrial matrix; mitochondrion; oxoglutarate dehydrogenase complex; nucleus;
Biological process	glycolytic process; olfactory bulb mitral cell layer development; thalamus development; generation of precursor metabolites and energy; tangential migration from the subventricular zone to the olfactory bulb; NADH metabolic process; cerebellar cortex development; pyramidal neuron development; metabolism; hippocampus development; striatum development; 2-oxoglutarate metabolic process; succinyl-CoA metabolic process; histone succinylation; tricarboxylic acid cycle; lysine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4967
	18293
	ENSG00000105953
	ENSMUSG00000020456
	Q02218
	Q60597
	NM_001003941; NM_001165036; NM_002541; NM_001363523
NM_001252282; NM_001252283; NM_001252287; NM_001252288; NM_010956;
	NM_001361902; NM_001361903; NM_001361904; NM_001361905
	NP_001003941; NP_001158508; NP_002532; NP_001350452
NP_001239211; NP_001239212; NP_001239216; NP_001239217; NP_035086;
	NP_001348831; NP_001348832; NP_001348833; NP_001348834
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-ketoglutarate dehydrogenase also known as 2-oxoglutarate dehydrogenase E1 component, mitochondrial is an enzyme that in humans is encoded by the OGDH gene.