Osteoglycin

OGN
Identifiers
Aliases	OGN, OG, OIF, SLRR3A, osteoglycin
External IDs	OMIM: 602383; MGI: 109278; HomoloGene: 8542; GeneCards: OGN; OMA:OGN - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	92,404,696 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	49,777,977 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; Descending thoracic aorta; ; parietal pleura; ; ascending aorta; ; gallbladder; ; decidua; ; left coronary artery; ; tendon of biceps brachii; ; cartilage tissue; ; vena cava;
	Top expressed in
	tunica media of zone of aorta; ; sciatic nerve; ; calvaria; ; epithelium of lens; ; ciliary body; ; cervix; ; left lung; ; carotid body; ; efferent ductule; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; growth factor activity; extracellular matrix structural constituent conferring compression resistance;
Cellular component	extracellular vesicle; extracellular matrix; lysosomal lumen; Golgi lumen; extracellular exosome; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	negative regulation of smooth muscle cell proliferation; axonogenesis; keratan sulfate catabolic process; keratan sulfate biosynthetic process; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4969
	18295
	ENSG00000106809
	ENSMUSG00000021390
	P20774
	Q62000
	NM_033014; NM_014057; NM_024416
	NM_008760
	NP_054776; NP_077727; NP_148935; NP_054776.1; NP_148935.1
	NP_032786
	Wikidata
View/Edit Human	View/Edit Mouse

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small keratan sulfate proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.

The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.