Olfactomedin 1

OLFM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XAT
Identifiers
Aliases	OLFM1, AMY, NOE1, NOELIN1, OlfA, olfactomedin 1
External IDs	OMIM: 605366; MGI: 1860437; HomoloGene: 8612; GeneCards: OLFM1; OMA:OLFM1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	135,121,180 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,120,748 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 10; ; frontal pole; ; primary visual cortex; ; superior frontal gyrus; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; orbitofrontal cortex; ; Brodmann area 46; ; Brodmann area 23;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; hippocampus proper; ; primary motor cortex; ; prefrontal cortex; ; piriform cortex; ; anterior amygdaloid area; ; subiculum; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; cell junction; axon; soma; perikaryon; axonal growth cone; synapse; cell projection; endoplasmic reticulum; extracellular space;
Biological process	multicellular organism development; atrioventricular valve formation; neuronal signal transduction; positive regulation of gene expression; regulation of axon extension; positive regulation of epithelial to mesenchymal transition; negative regulation of gene expression; nervous system development; cardiac epithelial to mesenchymal transition; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	10439
	56177
	ENSG00000130558
	ENSMUSG00000026833
	Q99784
	O88998
	NM_058199; NM_001282611; NM_001282612; NM_006334; NM_014279
	NM_001038612; NM_001038613; NM_001038614; NM_019498
	NP_001269540; NP_001269541; NP_006325; NP_055094
	NP_001033701; NP_001033702; NP_001033703; NP_062371
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactomedin 1, also known as noelin 1 or pancortin, is a protein that in humans is encoded by the OLFM1 gene. The name noelin stands for "neuronal olfactomedin-related endoplasmic reticulum-localized 1".

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.