Dynamin-like 120 kDa protein

OPA1
Identifiers
Aliases	OPA1, MGM1, NPG, NTG, largeG, Optic atrophy 1, BERHS, MTDPS14, mitochondrial dynamin like GTPase, OPA1 mitochondrial dynamin like GTPase
External IDs	OMIM: 605290; MGI: 1921393; HomoloGene: 14618; GeneCards: OPA1; OMA:OPA1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	193,697,811 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	29,473,702 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; endothelial cell; ; secondary oocyte; ; lateral nuclear group of thalamus; ; Brodmann area 23; ; middle temporal gyrus; ; right ventricle; ; monocyte; ; rectum; ; superior frontal gyrus;
	Top expressed in
	dorsal striatum; ; olfactory tubercle; ; nucleus accumbens; ; pontine nuclei; ; temporal lobe; ; Region I of hippocampus proper; ; subiculum; ; medial vestibular nucleus; ; myocardium of ventricle; ; substantia nigra;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; hydrolase activity; magnesium ion binding; microtubule binding; GTPase activity; phosphatidic acid binding; cardiolipin binding; lipid binding; kinase binding;
Cellular component	integral component of membrane; membrane; mitochondrial intermembrane space; nucleoplasm; mitochondrial outer membrane; extrinsic component of mitochondrial inner membrane; dendrite; mitochondrial crista; mitochondrion; axon cytoplasm; mitochondrial inner membrane; mitochondrial membranes; cytosol; cytoplasm;
Biological process	mitochondrial fusion; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; inner mitochondrial membrane organization; mitochondrial genome maintenance; mitochondrial fission; response to stimulus; negative regulation of release of cytochrome c from mitochondria; ageing; mitochondrion organization; positive regulation of dendrite development; cellular senescence; axonal transport of mitochondrion; positive regulation of mitochondrial fusion; positive regulation of neuron maturation; visual perception; apoptotic process; dynamin family protein polymerization involved in mitochondrial fission; regulation of apoptotic process; intracellular distribution of mitochondria; positive regulation of dendritic spine morphogenesis; mitochondrion morphogenesis; response to muscle activity; GTP metabolic process; cellular response to glucose stimulus; cellular response to hypoxia; membrane tubulation; response to electrical stimulus; response to nutrient levels; protein complex oligomerization; calcium import into the mitochondrion; retina development in camera-type eye; cochlea development; positive regulation of cellular response to insulin stimulus; cellular response to L-glutamate; negative regulation of apoptotic process; positive regulation of insulin receptor signaling pathway; membrane fusion; response to curcumin;
	Sources:Amigo / QuickGO
Orthologs
	4976
	74143
	ENSG00000198836
	ENSMUSG00000038084
	O60313
	P58281
NM_015560; NM_130831; NM_130832; NM_130833; NM_130834;
	NM_130835; NM_130836; NM_130837; NM_001354663; NM_001354664
	NM_001199177; NM_133752
NP_056375; NP_570844; NP_570845; NP_570846; NP_570847;
	NP_570848; NP_570849; NP_570850; NP_001341592; NP_001341593
NP_001186106; NP_598513; NP_001390099; NP_001390100; NP_001390101;
	NP_001390111
	Wikidata
View/Edit Human	View/Edit Mouse

Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis, and small, round mitochondria. Mutations in this gene have been implicated in dominant optic atrophy (DOA), leading to loss in vision, hearing, muscle contraction, and related dysfunctions.