OPN1LW

OPN1LW
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	8IU2
Identifiers
Aliases	OPN1LW, CBBM, CBP, COD5, RCP, ROP, opsin 1 (cone pigments), long-wave-sensitive, opsin 1, long wave sensitive
External IDs	OMIM: 300822; MGI: 1097692; HomoloGene: 68064; GeneCards: OPN1LW; OMA:OPN1LW - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,159,032 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,194,366 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; blood; ; left uterine tube; ; skin of leg; ; left adrenal cortex; ; lobe of thyroid gland; ; left lobe of thyroid gland; ; ascending aorta; ; right ovary; ; prostate;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; retinal pigment epithelium; ; epithelium of lens; ; embryo; ; outer nuclear layer; ; knee joint; ; soleus muscle; ; skeletal muscle tissue; ; quadriceps femoris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; photoreceptor activity; signal transducer activity; G protein-coupled photoreceptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; photoreceptor outer segment; photoreceptor disc membrane;
Biological process	positive regulation of cytokinesis; signal transduction; visual perception; retinoid metabolic process; response to stimulus; phototransduction; detection of visible light; G protein-coupled receptor signaling pathway; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5956
	14539
	ENSG00000102076
	ENSMUSG00000031394
	P04000
	O35599
	NM_020061
	NM_008106
	NP_064445
	NP_032132
	Wikidata
View/Edit Human	View/Edit Mouse

OPN1LW is a gene on the X chromosome that encodes for long wave sensitive (LWS) opsin, or red cone photopigment. The OPN1LW gene provides instructions for making an opsin pigment that is more sensitive to light in the yellow/orange part of the visible spectrum (long-wavelength light). The gene contains 6 exons with variability that induces shifts in the spectral range. OPN1LW is subject to homologous recombination with OPN1MW, as the two have very similar sequences. These recombinations can lead to various vision problems, such as red-green colourblindness and blue monochromacy. The protein encoded is a G-protein coupled receptor with embedded 11-cis-retinal, whose light excitation causes a cis-trans conformational change that begins the process of chemical signalling to the brain.

It is responsible for perception of visible light in the yellow-green range on the visible spectrum (around 500-570nm).