OPN1SW

OPN1SW
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KPN
Identifiers
Aliases	OPN1SW, BCP, BOP, CBT, opsin 1 (cone pigments), short-wave-sensitive, opsin 1, short wave sensitive
External IDs	OMIM: 613522; MGI: 99438; HomoloGene: 1291; GeneCards: OPN1SW; OMA:OPN1SW - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,775,794 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	29,388,467 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Brodmann area 46; ; stromal cell of endometrium; ; retinal pigment epithelium; ; Achilles tendon; ; Descending thoracic aorta; ; apex of heart; ; prefrontal cortex; ; ganglionic eminence; ; exocrine gland;
	Top expressed in
	blastocyst; ; neural layer of retina; ; epithelium of lens; ; outer nuclear layer; ; retinal pigment epithelium; ; lumbar subsegment of spinal cord; ; embryo; ; morula; ; lumbar spinal ganglion; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; photoreceptor activity; signal transducer activity; G protein-coupled photoreceptor activity; signaling receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; photoreceptor outer segment; photoreceptor disc membrane;
Biological process	response to stimulus; signal transduction; visual perception; retinoid metabolic process; phototransduction; detection of visible light; G protein-coupled receptor signaling pathway; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	611
	12057
	ENSG00000128617
	ENSMUSG00000058831
	P03999
	P51491
	NM_001708; NM_001385125
	NM_007538
	NP_001699
	NP_031564
	Wikidata
View/Edit Human	View/Edit Mouse

Blue-sensitive opsin is a protein that in humans is encoded by the OPN1SW gene. The OPN1SW gene provides instructions for making a protein that is essential for normal color vision. This protein is found in the retina, which is the light-sensitive tissue at the back of the eye.

The OPN1SW gene provides instructions for making an opsin pigment that is more sensitive to light in the blue/violet part of the visible spectrum (short-wavelength light). Cones with this pigment are called short-wavelength-sensitive or S cones. In response to light, the photopigment triggers a series of chemical reactions within an S cone. These reactions ultimately alter the cell's electrical charge, generating a signal that is transmitted to the brain. The brain combines input from all three types of cones to produce normal color vision.