ORM1

ORM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KQ0
Identifiers
Aliases	ORM1, AGP-A, AGP1, HEL-S-153w, ORM, orosomucoid 1
External IDs	OMIM: 138600; MGI: 97445; HomoloGene: 128040; GeneCards: ORM1; OMA:ORM1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	114,326,479 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	63,277,748 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; bone marrow; ; bone marrow cells; ; blood; ; trabecular bone; ; granulocyte; ; right lung; ; right adrenal gland; ; upper lobe of left lung;
	Top expressed in
	seminal vesicula; ; granulocyte; ; embryo; ; adrenal gland; ; white adipose tissue; ; liver; ; brown adipose tissue; ; tunica adventitia of aorta; ; left lobe of liver; ; neural layer of retina;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	blood microparticle; extracellular exosome; platelet alpha granule lumen; extracellular space; specific granule lumen; tertiary granule lumen; extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; regulation of immune system process; inflammatory response; acute-phase response; platelet degranulation; neutrophil degranulation; transport;
	Sources:Amigo / QuickGO
Orthologs
	5004
	18407
	ENSG00000229314
	ENSMUSG00000028359
	P02763
	Q63805
	NM_000607
	NM_013623; NM_001379520; NM_001379521
	NP_000598
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.