OSBP2

OSBP2
Identifiers
Aliases	OSBP2, HLM, ORP-4, ORP4, OSBPL1, OSBPL4, oxysterol binding protein 2
External IDs	OMIM: 606729; MGI: 1921559; HomoloGene: 75303; GeneCards: OSBP2; OMA:OSBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,907,824 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,813,903 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; left testis; ; right testis; ; monocyte; ; right hemisphere of cerebellum; ; blood; ; prefrontal cortex; ; right frontal lobe; ; trabecular bone; ; male germ cell;
	Top expressed in
	spermatid; ; neural layer of retina; ; interventricular septum; ; seminiferous tubule; ; spermatocyte; ; visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; retinal pigment epithelium; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cholesterol binding; protein binding; lipid binding; sterol transporter activity; sterol binding;
Cellular component	membrane; apical dendrite; cytosol; plasma membrane; intracellular membrane-bounded organelle; perinuclear endoplasmic reticulum;
Biological process	lipid transport; spermatid development; sterol transport;
	Sources:Amigo / QuickGO
Orthologs
	23762
	74309
	ENSG00000184792
	ENSMUSG00000020435
	Q969R2
	Q5QNQ6
NM_001003812; NM_001282738; NM_001282739; NM_001282740; NM_001282741;
	NM_001282742; NM_030758
	NM_152818; NM_001302630; NM_001302631; NM_001363163; NM_001363164
NP_001269667; NP_001269668; NP_001269669; NP_001269670; NP_001269671;
	NP_110385
	NP_001289559; NP_001289560; NP_690031; NP_001350092; NP_001350093
	Wikidata
View/Edit Human	View/Edit Mouse

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.

Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.