OTUD4

OTUD4
Identifiers
Aliases	OTUD4, DUBA6, HIN1, HSHIN1, OTU deubiquitinase 4
External IDs	OMIM: 611744; MGI: 1098801; HomoloGene: 35370; GeneCards: OTUD4; OMA:OTUD4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	145,180,589 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	80,404,353 bp
RNA expression pattern
	Top expressed in
	middle frontal gyrus; ; Brodmann area 10; ; paraflocculus of cerebellum; ; Skeletal muscle tissue of rectus abdominis; ; frontal pole; ; thoracic diaphragm; ; body of tongue; ; biceps brachii; ; cerebellar vermis; ; epithelium of nasopharynx;
	Top expressed in
	otic placode; ; Ileal epithelium; ; saccule; ; otic vesicle; ; cumulus cell; ; Gonadal ridge; ; secondary oocyte; ; tail of embryo; ; zygote; ; atrioventricular valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	thiol-dependent deubiquitinase; peptidase activity; cysteine-type peptidase activity; protein binding; hydrolase activity; RNA binding; molecular adaptor activity; Lys63-specific deubiquitinase activity;
Cellular component	cellular component; nucleus; cytoplasm;
Biological process	protein K48-linked deubiquitination; proteolysis; immune system process; negative regulation of toll-like receptor signaling pathway; innate immune response; protein K63-linked deubiquitination; positive regulation of DNA demethylation; regulation of protein K48-linked deubiquitination; negative regulation of interleukin-1-mediated signaling pathway; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	54726
	73945
	ENSG00000164164
	ENSMUSG00000036990
	Q01804
	B2RRE7
	NM_001102653; NM_017493; NM_199324; NM_001366057; NM_001366058
	NM_001081164; NM_001256033
	NP_001096123; NP_059963; NP_001352986; NP_001352987
	NP_001074633; NP_001242962
	Wikidata
View/Edit Human	View/Edit Mouse

OTU domain-containing protein 4 is a protein that in humans is encoded by the OTUD4 gene.

Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells.