Ohio State–Penn State football rivalry
| First meeting | November 16, 1912 Penn State, 37–0  | 
|---|---|
| Latest meeting | November 2, 2024 Ohio State, 20–13  | 
| Next meeting | November 1, 2025 | 
| Stadiums | Ohio State: Ohio Stadium Penn State: Beaver Stadium  | 
| Statistics | |
| Meetings total | 40 | 
| All-time series | Ohio State: 25–14 | 
| Largest victory | Ohio State: 63–14(2013) Penn State: 63–14(1994)  | 
| Longest win streak | Ohio State: 8 (2017–present) Penn State: 4 (1912–1964)  | 
| Current win streak | Ohio State: 8 (2017–present) | 
The Ohio State–Penn State football rivalry is an American college football rivalry between the Ohio State Buckeyes and the Penn State Nittany Lions. Ohio State leads the series 25–14.
The programs met eight times prior to the 1993 season when Penn State joined the Big Ten Conference. From 1993 through 2023, the teams played annually as a "protected rivalry" from 1993 to 2010, and as a divisional matchup from 2011 to 2023. This was not included as a protected rivalry when the Big Ten expanded in 2024; the teams will now meet at least twice in a five-year cycle.
The rivalry is marked by several memorable games, including Penn State’s blocked field goal return for a touchdown in 2016 and Ohio State’s fourth quarter comebacks in 2017 and 2018. Due to frequency of both teams being ranked when they meet, the rivalry is the most common matchup featured on ESPN's College Gameday, as the show has aired from either Columbus or State College for a record 13 times.