Olmesartan

Olmesartan
Clinical data
Trade names	Benicar
Other names	Olmesartan medoxomil
AHFS/Drugs.com	Monograph
MedlinePlus	a603006
License data	US DailyMed: Olmesartan;
Routes of; administration	Oral
ATC code	C09CA08 (WHO) ; C09DA08 (WHO) (with diuretics); C09DB02 (WHO) (with amlodipine);
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	26%
Metabolism	Liver (cannot be removed by hemodialysis)
Elimination half-life	13 hours
Excretion	Kidney 40%, bile duct 60%
Identifiers
	IUPAC name (5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylate;
CAS Number	144689-63-4 ;
PubChem CID	130881;
IUPHAR/BPS	591;
DrugBank	DB00275 ;
ChemSpider	115748 ;
UNII	6M97XTV3HD;
KEGG	D01204 ;
ChEBI	CHEBI:31932 ;
ChEMBL	ChEMBL1200692 ;
CompTox Dashboard (EPA)	DTXSID2040571 ;
ECHA InfoCard	100.174.243
Chemical and physical data
Formula	C29H30N6O6
Molar mass	558.595 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCc1nc(c(n1Cc2ccc(cc2)c3ccccc3c4[nH]nnn4)C(=O)OCc5c(oc(=O)o5)C)C(C)(C)O;
	InChI InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34) ; Key:UQGKUQLKSCSZGY-UHFFFAOYSA-N ;
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Olmesartan, sold under the brand name Benicar among others, is a medication used to treat high blood pressure (hypertension). It is taken orally (swallowed by mouth). Versions are available as the combination olmesartan/hydrochlorothiazide and olmesartan/amlodipine. It is available as a prodrug, olmesartan medoxomil.

Common side effects include dizziness, headaches, diarrhea, and back pain. Serious side effects may include kidney problems, low blood pressure, and angioedema. Use in pregnancy may harm the fetus and use when breastfeeding is not recommended. It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.

It was patented in 1991 and came into medical use in 2002. It is available as a generic medication. In 2022, it was the 97th most commonly prescribed medication in the United States, with more than 6 million prescriptions.