Olopatadine

Olopatadine
Clinical data
Trade names	Patanol, Pataday, Opatanol
AHFS/Drugs.com	Monograph
MedlinePlus	a602025
License data	US DailyMed: Olopatadine;
Pregnancy; category	AU: B1;
Routes of; administration	Eye drops, nasal spray
ATC code	S01GX09 (WHO) R01AC08 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only / OTC; EU: Rx-only;
Pharmacokinetic data
Elimination half-life	3 hours
Identifiers
	IUPAC name {(11Z)-11-[3-(dimethylamino)propylidene]-6,11-; dihydrodibenzo[b,e]oxepin-2-yl}acetic acid;
CAS Number	113806-05-6 ;
PubChem CID	5281071;
DrugBank	DB00768 ;
ChemSpider	4444528 ;
UNII	D27V6190PM;
KEGG	D08293 ; as HCl: D01192 ;
ChEMBL	ChEMBL1189432 ;
CompTox Dashboard (EPA)	DTXSID20150556 ;
Chemical and physical data
Formula	C21H23NO3
Molar mass	337.419 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)Cc2ccc1OCc3c(C(\c1c2)=C\CCN(C)C)cccc3;
	InChI InChI=1S/C21H23NO3/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24)/b18-8- ; Key:JBIMVDZLSHOPLA-LSCVHKIXSA-N ;
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Olopatadine, sold under the brand name Patanol among others, is an antihistamine medication used to decrease the symptoms of allergic conjunctivitis and allergic rhinitis (hay fever). It is used as eye drops or as a nasal spray. The eye drops generally result in an improvement within half an hour.

Common side effects include headache, sore throat, eye discomfort, or changes in perception of taste. More significant side effects may include sleepiness. It is unclear if use during pregnancy or breastfeeding is safe. It is an antihistamine and mast cell stabilizer.

Olopatadine was patented in 1986 and came into medical use in 1997. It is available as a generic medication. In 2022, it was the 250th most commonly prescribed medication in the United States, with more than 1 million prescriptions.