Ontario Highway 52

King's Highway 52, commonly referred to as Highway 52, was a provincially maintained highway located in the former Regional Municipality of Hamilton-Wentworth, now the City of Hamilton. The route began at a junction with former Highway 2 and Highway 53 near Ancaster and travelled north to Highway 5 and Highway 8 in Peters Corners. An older section travelled concurrently with Highway 8 northwest to Rockton, where it turned north and travelled to the Hamilton–Wellington boundary, ending inexplicably at a township road.

Highway 52 was first established in 1937 and 1938. The route remained unchanged until the formation of Hamilton-Wentworth, after which the portion north of Highway 8 was transferred to the region in 1987. The remainder between Highway 53 and Peters Corners was transferred to the region in 1998.