Osmeña
Osmeña may refer to:
- Sergio Osmeña (1878–1961), President of the Philippines
- Sergio Osmeña, Zamboanga del Norte, a municipality in the Philippines
- Sergio Osmeña Jr. (1918–1984), his son, senator
- John Henry Osmeña (1935–2021), also known as Sonny Osmeña, his grandson, senator
- Lito Osmeña (Emilio Mario Renner Osmeña Jr, 1938–2021), governor of Cebu, his grandson
- Serge Osmeña (Sergio de la Rama Osmeña III]] (born 1943), senator, his grandson
- Tomas Osmeña (born 1948), mayor of Cebu City, his grandson
- Osmeña pearl, made by polishing the shell of a nautilus