Primetime Emmy Award for Outstanding Lead Actor in a Comedy Series

This is a list of winners and nominees of the Primetime Emmy Award for Outstanding Lead Actor in a Comedy Series. The award is presented to the best performance by a lead actor in a television comedy series. Beginning with the 18th Primetime Emmy Awards, leading actors in comedy have competed alone. However, these comedic performances included actors from miniseries, telefilms, and guest performers competing against main cast competitors. Such instances are marked below:

• # – Indicates a performance in a miniseries or television film, prior to the category's creation
• § – Indicates a performance as a guest performer, prior to the category's creation

The 74th Primetime Emmy Awards are the first Emmys where there is no representation from any of the big four broadcast networks.