Oxitriptan

Oxitriptan
Clinical data
Trade namesCincofarm, Levothym, Levotonine, Oxyfan, Serovit, Telesol, Trimag, Tript-OH, Triptum
Other namesOxytryptan; 5-Hydroxytryptophan; L-5-Hydroxytryptophan; 5-Hydroxy-L-tryptophan; L-5-HTP; 5-HTP; α-Carboxy-5-hydroxytryptamine; α-Carboxy-5-HT
Routes of
administration		Oral
Drug classSerotonin precursor; Serotonin receptor agonist
ATC code
Pharmacokinetic data
Bioavailability49 ± 19%
With carbidopa: up to 84%
MetabolismDecarboxylation
Metabolites• Serotonin
Elimination half-lifeOral: 4.4–7 hours
IV: 2.2–7.4 hours
Identifiers
  • (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC11H12N2O3
Molar mass220.228 g·mol−1
3D model (JSmol)
  • C1=CC2=C(C=C1O)C(=CN2)C[C@@H](C(=O)O)N
  • InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
  • Key:LDCYZAJDBXYCGN-VIFPVBQESA-N

Oxitriptan, also known as L-5-hydroxytryptophan (5-HTP) and sold under various brand names, is a medication and over-the-counter dietary supplement used in the treatment of depression and for other indications. It is taken by mouth.

Side effects of oxitriptan include appetite loss, nausea, diarrhea, vomiting, and serotonin syndrome. The drug is a centrally permeable monoamine precursor and prodrug of serotonin and hence acts as a serotonin receptor agonist. Chemically, oxitriptan is an amino acid and a tryptamine.

Oxitriptan has been used clinically since at least the 1970s.

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