P2RX2

P2RX2
Identifiers
Aliases	P2RX2, DFNA41, P2X2, purinergic receptor P2X 2
External IDs	OMIM: 600844; MGI: 2665170; HomoloGene: 14251; GeneCards: P2RX2; OMA:P2RX2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	132,622,388 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	110,491,078 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right lung; ; right uterine tube; ; prostate; ; caput epididymis; ; tail of epididymis; ; corpus epididymis; ; hippocampus proper; ; spleen; ; upper lobe of left lung;
	Top expressed in
	vestibular membrane of cochlear duct; ; otolith organ; ; utricle; ; seminiferous tubule; ; spermatocyte; ; ganglion of vagus nerve; ; spermatid; ; vestibular sensory epithelium; ; cochlea; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	purinergic nucleotide receptor activity; extracellularly ATP-gated cation channel activity; ion channel activity; ligand-gated ion channel activity; identical protein binding; ATP binding; ATP-gated ion channel activity;
Cellular component	integral component of membrane; membrane; receptor complex; integral component of nuclear inner membrane; integral component of plasma membrane; intracellular anatomical structure; apical plasma membrane; plasma membrane; postsynapse; soma;
Biological process	peristalsis; response to ATP; positive regulation of calcium-mediated signaling; response to hypoxia; positive regulation of calcium ion transport into cytosol; urinary bladder smooth muscle contraction; hearing; ion transport; response to organic substance; cation transmembrane transport; neuromuscular synaptic transmission; behavioral response to pain; neuromuscular junction development; skeletal muscle fiber development; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling; protein homooligomerization; response to carbohydrate; sensory perception of taste; chemical synaptic transmission; blood coagulation; purinergic nucleotide receptor signaling pathway; excitatory postsynaptic potential; response to ischemia; cation transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	22953
	231602
	ENSG00000187848
	ENSMUSG00000029503
	Q9UBL9
	Q8K3P1
NM_001282164; NM_001282165; NM_012226; NM_016318; NM_170682;
	NM_170683; NM_174872; NM_174873
	NM_001164833; NM_001164834; NM_153400; NM_001310700; NM_001310701
NP_001269093; NP_001269094; NP_036358; NP_057402; NP_733782;
	NP_733783; NP_777361; NP_777362
	NP_001158305; NP_001158306; NP_001297629; NP_001297630; NP_700449
	Wikidata
View/Edit Human	View/Edit Mouse

P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a cation conducting ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.