P2RX5

P2RX5
Identifiers
Aliases	P2RX5, LRH-1, P2X5, P2X5R, purinergic receptor P2X 5
External IDs	OMIM: 602836; MGI: 2137026; HomoloGene: 1924; GeneCards: P2RX5; OMA:P2RX5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,696,240 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	73,063,511 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; appendix; ; granulocyte; ; mucosa of ileum; ; blood; ; apex of heart; ; gastrocnemius muscle; ; bone marrow cells; ; glutes;
	Top expressed in
	brown adipose tissue; ; soleus muscle; ; masseter muscle; ; facial motor nucleus; ; ascending aorta; ; intercostal muscle; ; myocardium of ventricle; ; motor neuron; ; muscle of thigh; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; ATP binding; transmembrane signaling receptor activity; purinergic nucleotide receptor activity; extracellularly ATP-gated cation channel activity; ATP-gated ion channel activity;
Cellular component	integral component of membrane; integral component of nuclear inner membrane; integral component of plasma membrane; membrane; plasma membrane; cytosol; postsynapse;
Biological process	response to ATP; positive regulation of calcium-mediated signaling; ion transport; positive regulation of calcium ion transport into cytosol; cation transmembrane transport; signal transduction; nervous system development; blood coagulation; purinergic nucleotide receptor signaling pathway; excitatory postsynaptic potential; cation transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	5026
	94045
	ENSG00000083454
	ENSMUSG00000005950
	Q93086
	n/a
	NM_175081; NM_001204519; NM_001204520; NM_002561; NM_175080
	NM_033321; NM_001376982; NM_001376983
	NP_001191448; NP_001191449; NP_002552; NP_778255
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

P2X purinoceptor 5 is a protein in humans that is encoded by the P2RX5 gene.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.