P2RX6

P2RX6
Identifiers
Aliases	P2RX6, P2RXL1, P2X6, P2XM, purinergic receptor P2X 6
External IDs	OMIM: 608077; MGI: 1337113; HomoloGene: 3975; GeneCards: P2RX6; OMA:P2RX6 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	21,028,013 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,395,664 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; right frontal lobe; ; right uterine tube; ; Brodmann area 9; ; apex of heart; ; spleen; ; anterior cingulate cortex; ; anterior pituitary; ; prefrontal cortex;
	Top expressed in
	facial motor nucleus; ; muscle of thigh; ; skeletal muscle tissue; ; soleus muscle; ; quadriceps femoris muscle; ; morula; ; medial head of gastrocnemius muscle; ; temporal muscle; ; masseter muscle; ; anterior horn of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	channel activity; purinergic nucleotide receptor activity; extracellularly ATP-gated cation channel activity; ion channel activity; identical protein binding; ATP binding; transmembrane signaling receptor activity; ATP-gated ion channel activity;
Cellular component	cytoplasm; integral component of membrane; membrane; integral component of nuclear inner membrane; integral component of plasma membrane; cell junction; plasma membrane; postsynapse; postsynaptic density; soma; dendritic spine; parallel fiber to Purkinje cell synapse; glutamatergic synapse; integral component of postsynaptic specialization membrane;
Biological process	response to ATP; muscle contraction; ion transport; cation transmembrane transport; protein homooligomerization; signal transduction; blood coagulation; purinergic nucleotide receptor signaling pathway; excitatory postsynaptic potential; protein heterooligomerization; cation transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9127
	18440
	ENSG00000099957
	ENSMUSG00000022758
	O15547
	O54803
NM_001159554; NM_005446; NM_001349874; NM_001349875; NM_001349876;
	NM_001394691; NM_001394692; NM_001394693; NM_001394694; NM_001394695; NM_001394696; NM_001394697
	NM_001159561; NM_011028
	NP_001153026; NP_005437; NP_001336803; NP_001336804; NP_001336805
	NP_001153033; NP_035158
	Wikidata
View/Edit Human	View/Edit Mouse

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.