P300-CBP coactivator family

E1A binding protein p300
Crystallographic structure of the histone acetyltransferase domain of EP300 (rainbow colored, N-terminus = blue, C-terminus = red) complexed with the inhibitor lysine-CoA (space-filling model, carbon = white, oxygen = red, nitrogen = blue, phosphorus = orange).
Identifiers
SymbolEP300
Alt. symbolsp300
NCBI gene2033
HGNC3373
OMIM602700
PDB3biy
RefSeqNM_001429
UniProtQ09472
Other data
EC number2.3.1.48
LocusChr. 22 q13.2
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StructuresSwiss-model
DomainsInterPro
CREB binding protein (CBP)
Structure of the TAZ2 domain (amino acids 1764–1850) of the mouse CREBBP protein. Based on PyMOL rendering of the structure PDB 1f81
Identifiers
SymbolCREBBP
Alt. symbolsCBP, RSTS
NCBI gene1387
HGNC2348
OMIM600140
PDB3dwy
RefSeqNM_004380
UniProtQ92793
Other data
EC number2.3.1.48
LocusChr. 16 p13.3
Search for
StructuresSwiss-model
DomainsInterPro

The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators):

  1. p300 (also called EP300 or E1A binding protein p300)
  2. CBP (also known as CREB-binding protein or CREBBP)

Both p300 and CBP interact with numerous transcription factors and act to increase the expression of their target genes.

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