P4HB

P4HB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X5C, 1BJX, 2K18, 4JU5, 4EL1, 3BJ5, 1MEK, 2BJX, 3UEM, 4EKZ
Identifiers
Aliases	P4HB, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB, CLCRP1, prolyl 4-hydroxylase subunit beta
External IDs	OMIM: 176790; MGI: 97464; HomoloGene: 55495; GeneCards: P4HB; OMA:P4HB - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,860,856 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,464,079 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; parotid gland; ; body of pancreas; ; jejunal mucosa; ; mucosa of ileum; ; islet of Langerhans; ; right lobe of liver; ; duodenum; ; anterior pituitary; ; beta cell;
	Top expressed in
	lacrimal gland; ; gastrula; ; crypt of lieberkuhn of small intestine; ; molar; ; parotid gland; ; Paneth cell; ; calvaria; ; renal corpuscle; ; submandibular gland; ; pyloric antrum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	isomerase activity; integrin binding; protein binding; procollagen-proline 4-dioxygenase activity; protein heterodimerization activity; enzyme binding; RNA binding; protein disulfide isomerase activity;
Cellular component	procollagen-proline 4-dioxygenase complex; endoplasmic reticulum lumen; membrane; focal adhesion; melanosome; plasma membrane; endoplasmic reticulum chaperone complex; extracellular region; endoplasmic reticulum; extracellular exosome; external side of plasma membrane; endoplasmic reticulum-Golgi intermediate compartment; extracellular matrix;
Biological process	positive regulation of viral entry into host cell; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; cell redox homeostasis; response to endoplasmic reticulum stress; cellular response to hypoxia; protein folding; chylomicron assembly; very-low-density lipoprotein particle assembly; cellular response to oxidative stress; post-translational protein modification; interleukin-12-mediated signaling pathway; interleukin-23-mediated signaling pathway; cellular response to interleukin-7;
	Sources:Amigo / QuickGO
Orthologs
	5034
	18453
	ENSG00000185624
	ENSMUSG00000025130
	P07237
	P09103
	NM_000918
	NM_011032
	NP_000909
	NP_035162
	Wikidata
View/Edit Human	View/Edit Mouse

Protein disulfide-isomerase, also known as the beta-subunit of prolyl 4-hydroxylase (P4HB), is an enzyme that in humans encoded by the P4HB gene. The human P4HB gene is localized in chromosome 17q25. Unlike other prolyl 4-hydroxylase family proteins, this protein is multifunctional and acts as an oxidoreductase for disulfide formation, breakage, and isomerization. The activity of P4HB is tightly regulated. Both dimer dissociation and substrate binding are likely to enhance its enzymatic activity during the catalysis process.