PAG1

PAG1
Identifiers
Aliases	PAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
External IDs	OMIM: 605767; MGI: 2443160; HomoloGene: 10198; GeneCards: PAG1; OMA:PAG1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	81,112,068 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	9,898,739 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; mucosa of ileum; ; visceral pleura; ; endothelial cell; ; lower lobe of lung; ; jejunal mucosa; ; spinal ganglia; ; mucosa of colon; ; mucosa of sigmoid colon; ; tibia;
	Top expressed in
	pineal gland; ; superior cervical ganglion; ; ciliary body; ; granulocyte; ; left lung lobe; ; substantia nigra; ; lateral septal nucleus; ; blood; ; trigeminal ganglion; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH2 domain binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity;
Cellular component	integral component of membrane; membrane raft; plasma membrane; membrane; integral component of plasma membrane; intracellular anatomical structure;
Biological process	intracellular signal transduction; T cell receptor signaling pathway; adaptive immune response; regulation of T cell activation; signal transduction; immune system process; positive regulation of signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of T cell activation;
	Sources:Amigo / QuickGO
Orthologs
	55824
	94212
	ENSG00000076641
	ENSMUSG00000027508
	Q9NWQ8
	Q3U1F9
	NM_018440; NM_001007549
	NM_001195031; NM_053182
	NP_060910
	NP_001181960; NP_444412
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.