Phosphoribosylaminoimidazole carboxylase
| Phosphoribosylaminoimidazole carboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Phosphoribosylaminoimidazole carboxylase octamer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 4.1.1.21 | ||||||||
| CAS no. | 9032-04-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PAICS | ||||||
| Alt. symbols | PAIS | ||||||
| NCBI gene | 10606 | ||||||
| HGNC | 8587 | ||||||
| OMIM | 172439 | ||||||
| RefSeq | NM_006452 | ||||||
| UniProt | P22234 | ||||||
| Other data | |||||||
| EC number | 4.1.1.21 | ||||||
| Locus | Chr. 4 pter-q21 | ||||||
| |||||||
The enzyme Phosphoribosylaminoimidazole carboxylase, or AIR carboxylase (EC 4.1.1.21) is involved in nucleotide biosynthesis and in particular in purine biosynthesis. It catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole ("AIR") into 5'-phosphoribosyl-4-carboxy-5-aminoimidazole ("CAIR") as described in the reaction:
- 5-aminoimidazole ribonucleotide + CO2 5'-phosphoribosyl-4-carboxy-5-aminoimidazole + 2 H+
