PAK1

PAK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F3M, 1YHW, 1ZSG, 2HY8, 2QME, 3DVP, 3FXZ, 3FY0, 3Q4Z, 3Q52, 3Q53, 4DAW, 4EQC, 4O0R, 4O0T, 4P90, 4ZJI, 4ZJJ, 4ZY4, 4ZY5, 4ZY6, 4ZLO, 5DFP, 5DEY, 5IME
Identifiers
Aliases	PAK1, PAKalpha, p21 (RAC1) activated kinase 1, IDDMSSD
External IDs	OMIM: 602590; MGI: 1339975; HomoloGene: 1936; GeneCards: PAK1; OMA:PAK1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,474,635 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	97,561,588 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; monocyte; ; endothelial cell; ; Pons; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; right frontal lobe; ; lateral nuclear group of thalamus;
	Top expressed in
	facial motor nucleus; ; motor neuron; ; pontine nuclei; ; zygote; ; anterior horn of spinal cord; ; inferior colliculi; ; piriform cortex; ; cerebellar cortex; ; genital tubercle; ; visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATP binding; collagen binding; protein binding; kinase activity; catalytic activity; nucleotide binding; transferase activity; protein serine/threonine kinase activity; protein kinase activity; identical protein binding; protein kinase binding;
Cellular component	cell projection; ruffle membrane; membrane; filamentous actin; cell-cell junction; cell junction; focal adhesion; cytoplasm; intercalated disc; dendrite; plasma membrane; Z discdkac; axon; nuclear membrane; ruffle; cytosol; lamellipodium; protein-containing complex; actin filament; nucleoplasm; nucleus; chromosome;
Biological process	positive regulation of protein phosphorylation; cellular response to insulin stimulus; negative regulation of cell proliferation involved in contact inhibition; response to hypoxia; exocytosis; positive regulation of JUN kinase activity; MAPK cascade; regulation of actin cytoskeleton organization; positive regulation of intracellular estrogen receptor signaling pathway; branching morphogenesis of an epithelial tube; ephrin receptor signaling pathway; positive regulation of stress fiber assembly; T cell costimulation; wound healing; positive regulation of cell migration; apoptotic process; Fc-gamma receptor signaling pathway involved in phagocytosis; Fc-epsilon receptor signaling pathway; phosphorylation; metabolism; stimulatory C-type lectin receptor signaling pathway; response to organic substance; T cell receptor signaling pathway; neuron projection morphogenesis; positive regulation of cell population proliferation; protein autophosphorylation; actin cytoskeleton reorganization; protein phosphorylation; Rho protein signal transduction; regulation of mitotic cell cycle; positive regulation of fibroblast migration; cerebellum development; establishment of cell polarity; positive regulation of microtubule polymerization; activation of protein kinase activity; positive regulation of peptidyl-serine phosphorylation; regulation of apoptotic process; positive regulation of axon extension; hepatocyte growth factor receptor signaling pathway; regulation of axonogenesis; negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of protein targeting to membrane; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell migration; signal transduction; stress-activated protein kinase signaling cascade; regulation of MAPK cascade; positive regulation of insulin receptor signaling pathway; cellular response to DNA damage stimulus; cell migration; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	5058
	18479
	ENSG00000149269
	ENSMUSG00000030774
	Q13153
	O88643
	NM_001128620; NM_002576
	NM_011035; NM_001357362; NM_001357363; NM_001357364; NM_001357365
NP_001122092; NP_002567; NP_001363197; NP_001363198; NP_001363199;
	NP_001363200; NP_001363201; NP_001363202; NP_001363203; NP_001363204; NP_001363205; NP_001363206; NP_001363207; NP_001363208; NP_001363209; NP_001363210; NP_001363211; NP_001363212; NP_001363213; NP_001363214; NP_001363215; NP_001363216; NP_001363217; NP_001363218; NP_001363219; NP_001363220; NP_001363221; NP_001363222; NP_001363223; NP_001363224; NP_001363230; NP_001363231; NP_001363232; NP_001363233; NP_001363234
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene.

PAK1 is one of six members of the PAK family of serine/threonine kinases which are broadly divided into group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK6 and PAK5/7). The PAKs are evolutionarily conserved. PAK1 localizes in distinct sub-cellular domains in the cytoplasm and nucleus. PAK1 regulates cytoskeleton remodeling, phenotypic signaling and gene expression, and affects a wide variety of cellular processes such as directional motility, invasion, metastasis, growth, cell cycle progression, angiogenesis. PAK1-signaling dependent cellular functions regulate both physiologic and disease processes, including cancer, as PAK1 is widely overexpressed and hyperstimulated in human cancer, at-large.