PAK2

PAK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PCS
Identifiers
Aliases	PAK2, PAK65, PAKgamma, p21 (RAC1) activated kinase 2
External IDs	OMIM: 605022; MGI: 1339984; HomoloGene: 99711; GeneCards: PAK2; OMA:PAK2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	196,832,647 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	31,898,160 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; corpus callosum; ; ventricular zone; ; monocyte; ; superficial temporal artery; ; Epithelium of choroid plexus; ; stromal cell of endometrium; ; Achilles tendon; ; pericardium; ; buccal mucosa cell;
	Top expressed in
	Paneth cell; ; granulocyte; ; Ileal epithelium; ; retinal pigment epithelium; ; aortic valve; ; ciliary body; ; vestibular membrane of cochlear duct; ; renal corpuscle; ; utricle; ; ascending aorta;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein tyrosine kinase activator activity; kinase activity; protein serine/threonine kinase activity; protein binding; catalytic activity; identical protein binding; ATP binding; protein kinase binding; cadherin binding; small GTPase binding;
Cellular component	membrane; plasma membrane; perinuclear region of cytoplasm; nucleus; cytoplasm; cytosol; postsynaptic density; glutamatergic synapse;
Biological process	negative regulation of protein kinase activity; phosphorylation; T cell costimulation; cellular response to organic cyclic compound; stimulatory C-type lectin receptor signaling pathway; mitigation of host defenses by virus; Fc-epsilon receptor signaling pathway; protein phosphorylation; dendritic spine development; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; vascular endothelial growth factor receptor signaling pathway; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of extrinsic apoptotic signaling pathway; protein autophosphorylation; regulation of growth; metabolism; T cell receptor signaling pathway; signal transduction; positive regulation of protein tyrosine kinase activity; apoptotic process; negative regulation of apoptotic process; viral process; Rho protein signal transduction; regulation of mitotic cell cycle; cell migration; actin cytoskeleton organization; stress-activated protein kinase signaling cascade; regulation of apoptotic process; regulation of MAPK cascade; interleukin-12-mediated signaling pathway; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	5062
	224105
	ENSG00000180370
	ENSMUSG00000022781
	Q13177
	Q8CIN4
	NM_002577
	NM_177326
	NP_002568
	NP_796300
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene.

PAK2 is one of three members of Group I PAK family of serine/threonine kinases. The PAKs are evolutionary conserved. PAK2 and its cleaved fragment localize in both the cytoplasmic or nuclear compartments. PAK2 signaling modulates apoptosis, endothelial lumen formation, viral pathogenesis, and cancer including, breast, hepatocarcinoma, gastric and cancer, at-large, and, based on its kinase activity alone, peripheral nerve myelination during embryonic development.