PAK4

PAK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BVA, 2CDZ, 2J0I, 2OV2, 2Q0N, 2X4Z, 4APP, 4FIE, 4FIF, 4FIG, 4FIH, 4FII, 4FIJ, 4JDH, 4JDI, 4JDJ, 4JDK, 4L67, 4NJD, 4O0V, 4O0X, 4O0Y, 5BMS, 4XBU, 4XBR
Identifiers
Aliases	PAK4, p21 (RAC1) activated kinase 4
External IDs	OMIM: 605451; MGI: 1917834; HomoloGene: 4300; GeneCards: PAK4; OMA:PAK4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,182,816 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,297,610 bp
RNA expression pattern
	Top expressed in
	beta cell; ; olfactory bulb; ; thoracic diaphragm; ; mucosa of transverse colon; ; right uterine tube; ; right lung; ; parotid gland; ; upper lobe of left lung; ; myocardium of left ventricle; ; anterior pituitary;
	Top expressed in
	zygote; ; secondary oocyte; ; yolk sac; ; epithelium of stomach; ; otolith organ; ; transitional epithelium of urinary bladder; ; hand; ; utricle; ; tail of embryo; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein binding; ATP binding; cadherin binding involved in cell-cell adhesion; protein serine/threonine kinase activity;
Cellular component	cytoplasm; Golgi apparatus; focal adhesion;
Biological process	phosphorylation; cellular response to organic cyclic compound; protein phosphorylation; cell growth; dendritic spine development; cytoskeleton organization; cell cycle; cell population proliferation; cell migration; signal transduction; apoptotic process; cell-cell adhesion; Rho protein signal transduction; regulation of mitotic cell cycle; actin cytoskeleton organization; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process; regulation of MAPK cascade; regulation of cell growth; positive regulation of angiogenesis; negative regulation of endothelial cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	10298
	70584
	ENSG00000130669
	ENSMUSG00000030602
	O96013
	Q8BTW9
NM_001014831; NM_001014832; NM_001014833; NM_001014834; NM_001014835;
	NM_005884; NM_001394501
	NM_027470
	NP_001014831; NP_001014832; NP_001014834; NP_001014835; NP_005875
	NP_081746
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.

PAK4 is one of six members of the PAK family of serine/threonine kinases which are divided into group I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK6 and PAK5/7). PAK4 localizes in sub-cellular domains of the cytoplasm and nucleus. PAK4 regulates cytoskeleton remodeling, phenotypic signaling and gene expression, and affects directional motility, invasion, metastasis, and growth. Similar to PAK1, PAK4-signaling-dependent cellular functions also regulate both physiologic and disease processes such as cancer, as PAK4 is overexpressed and/or hyperstimulated in human cancer, at-large.