PANX1

PANX1
Identifiers
Aliases	PANX1, MRS1, PX1, UNQ2529, pannexin 1, OOMD7, Pannexin1
External IDs	OMIM: 608420; MGI: 1860055; HomoloGene: 49416; GeneCards: PANX1; OMA:PANX1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	94,181,968 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,956,774 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; stromal cell of endometrium; ; secondary oocyte; ; islet of Langerhans; ; monocyte; ; ventricular zone; ; Achilles tendon; ; gastrocnemius muscle; ; testicle; ; right coronary artery;
	Top expressed in
	lumbar spinal ganglion; ; tail of embryo; ; intestinal villus; ; stroma of bone marrow; ; genital tubercle; ; ganglionic eminence; ; Rostral migratory stream; ; jejunum; ; ventricular zone; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter binding; calcium channel activity; channel activity; scaffold protein binding; gap junction channel activity; protease binding; actin filament binding; leak channel activity; protein heterodimerization activity; actin binding; gap junction hemi-channel activity; signaling receptor binding; wide pore channel activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; cell junction; bleb; gap junction; membrane; endoplasmic reticulum; plasma membrane; protein-containing complex;
Biological process	response to ATP; cation transport; ion transport; response to ischemia; calcium ion transmembrane transport; transmembrane transport; protein hexamerization; calcium ion transport; cell-cell signaling; transport;
	Sources:Amigo / QuickGO
Orthologs
	24145
	55991
	ENSG00000110218
	ENSMUSG00000031934
	Q96RD7
	Q9JIP4
	NM_015368
	NM_019482
	NP_056183
	NP_062355
	Wikidata
View/Edit Human	View/Edit Mouse

Pannexin 1 is a protein in humans that is encoded by the PANX1 gene.

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.