PAQR3

PAQR3
Identifiers
Aliases	PAQR3, RKTG, progestin and adipoQ receptor family member 3
External IDs	OMIM: 614577; MGI: 2679683; HomoloGene: 71077; GeneCards: PAQR3; OMA:PAQR3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	78,939,438 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	97,259,455 bp
RNA expression pattern
	Top expressed in
	sperm; ; jejunal mucosa; ; right testis; ; left testis; ; ganglionic eminence; ; testicle; ; skin of thigh; ; ventricular zone; ; Epithelium of choroid plexus; ; gonad;
	Top expressed in
	ganglionic eminence; ; lens; ; Mesencephalon; ; hippocampus proper; ; rhombencephalon; ; dentate gyrus of hippocampal formation granule cell; ; striatum of neuraxis; ; Cerebellum; ; neural tube; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; signaling receptor activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	negative regulation of protein phosphorylation; negative regulation of neuron projection development; MAPK cascade; negative regulation of MAP kinase activity; negative regulation of peptidyl-serine phosphorylation; protein localization to Golgi apparatus;
	Sources:Amigo / QuickGO
Orthologs
	152559
	231474
	ENSG00000163291
	ENSMUSG00000055725
	Q6TCH7
	Q6TCG8
	NM_001040202; NM_177453; NM_001350105; NM_001350106
	NM_198422; NM_001359910; NM_001359913
	NP_001035292; NP_001337034; NP_001337035
	NP_940814; NP_001346839; NP_001346842
	Wikidata
View/Edit Human	View/Edit Mouse

Progestin and adipoQ receptor family member 3 (PAQR3), or Raf Kinase Trapping to Golgi apparatus (RKTG) is a protein that in humans is encoded by the PAQR3 gene. It is a member of the progestin and adipoQ receptor (PAQR) family. PAQR3 is predicted to have seven transmembrane helices and to be localized to the Golgi Apparatus. It functions as a tumor suppressor by negatively regulating tumor cell proliferation and migration by inhibiting Raf kinase and AKT pathway. PAQR3 was also shown to modulate cholesterol homeostasis by anchoring the SCAP/SREBP complex to the Golgi under cholesterol depletion conditions.