DJ-1

PARK7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A, 3BWE, 3CY6, 3CYF, 3CZ9, 3CZA, 3EZG, 3F71, 3SF8, 4BTE, 4MNT, 4MTC, 4N0M, 4N12, 4OGF, 4OQ4, 4P2G, 4P34, 4P35, 4P36, 4ZGG, 4RKW, 4RKY, 4S0Z
Identifiers
Aliases	PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2
External IDs	OMIM: 602533; MGI: 2135637; HomoloGene: 38295; GeneCards: PARK7; OMA:PARK7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	7,985,505 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	150,998,894 bp
RNA expression pattern
	Top expressed in
	tibia; ; deltoid muscle; ; endothelial cell; ; Epithelium of choroid plexus; ; dorsal motor nucleus of vagus nerve; ; tibialis anterior muscle; ; Skeletal muscle tissue of biceps brachii; ; islet of Langerhans; ; vastus lateralis muscle; ; right ventricle;
	Top expressed in
	triceps brachii muscle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; medial head of gastrocnemius muscle; ; facial motor nucleus; ; tibialis anterior muscle; ; retinal pigment epithelium; ; Paneth cell; ; temporal muscle; ; extensor digitorum longus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; cytokine binding; cupric ion binding; transcription factor binding; L-dopa decarboxylase activator activity; peptidase activity; kinase binding; tyrosine 3-monooxygenase activator activity; enzyme binding; mRNA binding; protein homodimerization activity; scaffold protein binding; small protein activating enzyme binding; single-stranded DNA binding; ubiquitin-like protein conjugating enzyme binding; protein binding; peroxiredoxin activity; double-stranded DNA binding; copper ion binding; mercury ion binding; transcription coactivator activity; oxidoreductase activity, acting on peroxide as acceptor; androgen receptor binding; superoxide dismutase copper chaperone activity; RNA binding; identical protein binding; ubiquitin-specific protease binding; hydrolase activity; cuprous ion binding; cadherin binding; protein deglycase activity; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; membrane; mitochondrial intermembrane space; mitochondrion; neuron projection; nucleus; mitochondrial respiratory chain complex I; endoplasmic reticulum; membrane raft; chromatin; extracellular exosome; plasma membrane; mitochondrial matrix; cell body; PML body; presynapse; perinuclear region of cytoplasm; axon; nucleoplasm;
Biological process	negative regulation of neuron apoptotic process; positive regulation of transcription regulatory region DNA binding; negative regulation of protein sumoylation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of protein binding; synaptic transmission, dopaminergic; positive regulation of interleukin-8 production; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; Ras protein signal transduction; cellular response to glyoxal; negative regulation of protein acetylation; positive regulation of reactive oxygen species biosynthetic process; positive regulation of oxidative phosphorylation uncoupler activity; positive regulation of protein kinase B signaling; negative regulation of protein catabolic process; adult locomotory behavior; regulation of neuron apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of cell death; glycolate biosynthetic process; positive regulation of protein homodimerization activity; negative regulation of gene expression; single fertilization; positive regulation of peptidyl-serine phosphorylation; positive regulation of mitochondrial electron transport, NADH to ubiquinone; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway; negative regulation of oxidative stress-induced cell death; inflammatory response; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; regulation of supramolecular fiber organization; negative regulation of neuron death; negative regulation of protein phosphorylation; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein kinase activity; negative regulation of oxidative stress-induced neuron death; membrane depolarization; protein stabilization; mitochondrion organization; positive regulation of DNA-binding transcription factor activity; negative regulation of death-inducing signaling complex assembly; negative regulation of apoptotic process; proteolysis; negative regulation of protein K48-linked deubiquitination; dopamine uptake involved in synaptic transmission; positive regulation of tyrosine 3-monooxygenase activity; positive regulation of L-dopa decarboxylase activity; negative regulation of hydrogen peroxide-induced neuron death; regulation of inflammatory response; regulation of androgen receptor signaling pathway; negative regulation of hydrogen peroxide-induced cell death; positive regulation of autophagy of mitochondrion; response to hydrogen peroxide; detoxification of copper ion; positive regulation of superoxide dismutase activity; positive regulation of dopamine biosynthetic process; positive regulation of protein localization to nucleus; positive regulation of L-dopa biosynthetic process; activation of protein kinase B activity; membrane hyperpolarization; detoxification of mercury ion; negative regulation of TRAIL-activated apoptotic signaling pathway; cellular oxidant detoxification; negative regulation of ubiquitin-specific protease activity; autophagy; cellular response to reactive oxygen species; regulation of mitochondrial membrane potential; negative regulation of protein ubiquitination; hydrogen peroxide metabolic process; positive regulation of gene expression; negative regulation of protein export from nucleus; negative regulation of ubiquitin-protein transferase activity; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; cellular response to oxidative stress; positive regulation of androgen receptor activity; positive regulation of pyrroline-5-carboxylate reductase activity; positive regulation of transcription by RNA polymerase II; cellular response to hydrogen peroxide; methylglyoxal metabolic process; lactate biosynthetic process; peptidyl-cysteine deglycation; peptidyl-arginine deglycation; peptidyl-lysine deglycation; protein deglycation, glyoxal removal; protein deglycation, methylglyoxal removal; glutathione deglycation; glyoxal metabolic process; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; positive regulation of acute inflammatory response to antigenic stimulus; protein deglycosylation; positive regulation of NAD(P)H oxidase activity; DNA repair; cellular response to DNA damage stimulus; insulin secretion; glucose homeostasis; guanine deglycation; guanine deglycation, methylglyoxal removal; guanine deglycation, glyoxal removal; negative regulation of reactive oxygen species biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	11315
	57320
	ENSG00000116288
	ENSMUSG00000028964
	Q99497
	Q99LX0
	NM_001123377; NM_007262
	NM_020569
	NP_001116849; NP_009193
	NP_065594
	Wikidata
View/Edit Human	View/Edit Mouse

DJ1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Its weak glyoxalase activity has been verified by many labs, however the reported protein deglycase activity is likely to be an artifact stemming from DJ-1's ability to destroy free methylglyoxal.