Poly(A)-specific ribonuclease

PARN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A1R, 2A1S, 3CTR
Identifiers
Aliases	PARN, DAN, DKCB6, PFBMFT4, Poly(A)-specific ribonuclease
External IDs	OMIM: 604212; MGI: 1921358; HomoloGene: 31098; GeneCards: PARN; OMA:PARN - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	14,632,728 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	13,486,034 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; testicle; ; tonsil; ; epithelium of colon; ; gonad; ; bone marrow cells; ; smooth muscle tissue; ; islet of Langerhans; ; urinary bladder;
	Top expressed in
	aortic valve; ; ascending aorta; ; renal corpuscle; ; medullary collecting duct; ; Paneth cell; ; saccule; ; ectoderm; ; otic vesicle; ; otic placode; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; mRNA 3'-UTR binding; protein binding; nucleic acid binding; nuclease activity; exonuclease activity; hydrolase activity; protein kinase binding; cation binding; RNA binding; poly(A)-specific ribonuclease activity; telomerase RNA binding; 3'-5'-exoribonuclease activity;
Cellular component	cytoplasm; cytosol; nucleolus; nucleus;
Biological process	mRNA catabolic process; female gamete generation; regulation of mRNA stability; RNA modification; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA poly(A) tail shortening; RNA phosphodiester bond hydrolysis, exonucleolytic; telomerase RNA stabilization; positive regulation of telomere maintenance via telomerase; positive regulation of telomerase activity; regulation of telomerase RNA localization to Cajal body; ncRNA deadenylation; box H/ACA RNA 3'-end processing; miRNA catabolic process; polyadenylation-dependent snoRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	5073
	74108
	ENSG00000140694; ENSG00000274829
	ENSMUSG00000022685
	O95453
	Q8VDG3
	NM_001134477; NM_001242992; NM_002582
	NM_028761; NM_001358452; NM_001358453
	NP_001127949; NP_001229921; NP_002573
	NP_083037; NP_001345381; NP_001345382
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene.