PARP10

PARP10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DHX, 3HKV
Identifiers
Aliases	PARP10, ARTD10, poly(ADP-ribose) polymerase family member 10
External IDs	OMIM: 609564; MGI: 3712326; HomoloGene: 53133; GeneCards: PARP10; OMA:PARP10 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,012,772 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,127,641 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; pancreatic ductal cell; ; right uterine tube; ; spleen; ; appendix; ; lymph node; ; right testis; ; tendon of biceps brachii; ; left testis; ; right lobe of liver;
	Top expressed in
	granulocyte; ; thymus; ; right kidney; ; mesenteric lymph nodes; ; duodenum; ; lip; ; spleen; ; proximal tubule; ; left lobe of liver; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; K63-linked polyubiquitin modification-dependent protein binding; protein binding; glycosyltransferase activity; NAD+ ADP-ribosyltransferase activity; protein ADP-ribosylase activity;
Cellular component	cytoplasm; nucleus; nucleolus; cytosol; intracellular membrane-bounded organelle;
Biological process	negative regulation of protein K63-linked ubiquitination; protein auto-ADP-ribosylation; negative regulation of NF-kappaB transcription factor activity; protein ADP-ribosylation; negative regulation of fibroblast proliferation; negative regulation of gene expression; NAD biosynthesis via nicotinamide riboside salvage pathway; protein poly-ADP-ribosylation; translesion synthesis; protein mono-ADP-ribosylation; DNA repair; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	84875
	671535
	ENSG00000178685
	ENSMUSG00000063268
	Q53GL7
	Q8CIE4
	NM_032789; NM_001317895
	NM_001163575; NM_001163576
	NP_001304824; NP_116178
	NP_001157047; NP_001157048
	Wikidata
View/Edit Human	View/Edit Mouse

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM]