PARP4

PARP4
Identifiers
Aliases	PARP4, ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193, poly(ADP-ribose) polymerase family member 4
External IDs	OMIM: 607519; MGI: 2685589; HomoloGene: 124423; GeneCards: PARP4; OMA:PARP4 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	24,512,778 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,897,251 bp
RNA expression pattern
	Top expressed in
	rectum; ; duodenum; ; monocyte; ; gallbladder; ; bone marrow cells; ; blood; ; islet of Langerhans; ; transverse colon; ; Achilles tendon; ; endometrium;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; gastrula; ; transitional epithelium of urinary bladder; ; duodenum; ; muscle of thigh; ; spleen; ; zygote; ; conjunctival fornix; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; glycosyltransferase activity; protein binding; enzyme binding; NAD+ ADP-ribosyltransferase activity; protein ADP-ribosylase activity;
Cellular component	cytoplasm; membrane; spindle; spindle microtubule; extracellular exosome; cytoskeleton; nucleus; cytosol; ribonucleoprotein complex;
Biological process	protein ADP-ribosylation; cell death; cellular response to DNA damage stimulus; inflammatory response; DNA repair; regulation of telomerase activity; transport; protein mono-ADP-ribosylation;
	Sources:Amigo / QuickGO
Orthologs
	143
	328417
	ENSG00000102699
	ENSMUSG00000054509
	Q9UKK3
	E9PYK3
	NM_006437
	NM_001145978
	NP_006428
	NP_001139450
	Wikidata
View/Edit Human	View/Edit Mouse

Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.