PBK (gene)

PBK
Identifiers
Aliases	PBK, CT84, HEL164, Nori-3, SPK, TOPK, PDZ binding kinase
External IDs	OMIM: 611210; MGI: 1289156; HomoloGene: 32415; GeneCards: PBK; OMA:PBK - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	27,838,082 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	66,055,271 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; sperm; ; ganglionic eminence; ; gonad; ; left testis; ; right testis; ; secondary oocyte; ; testicle; ; mucosa of transverse colon; ; rectum;
	Top expressed in
	spermatocyte; ; medial ganglionic eminence; ; superior cervical ganglion; ; seminiferous tubule; ; endocardial cushion; ; Paneth cell; ; migratory enteric neural crest cell; ; ventricular zone; ; renal corpuscle; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein serine/threonine kinase activity; protein kinase activity; protein binding; ATP binding;
Cellular component	nucleus;
Biological process	cellular response to UV; negative regulation of protein phosphorylation; protein phosphorylation; negative regulation of stress-activated MAPK cascade; negative regulation of inflammatory response; phosphorylation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	55872
	52033
	55872
	ENSMUSG00000022033
	Q96KB5
	Q9JJ78
	NM_001278945; NM_018492; NM_001363040
	NM_023209
	NP_001265874; NP_060962; NP_001349969
	NP_075698
	Wikidata
View/Edit Human	View/Edit Mouse

Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene.

The protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.