PCBP3

PCBP3
Identifiers
Aliases	PCBP3, ALPHA-CP3, poly(rC) binding protein 3
External IDs	OMIM: 608502; MGI: 1890470; HomoloGene: 23233; GeneCards: PCBP3; OMA:PCBP3 - orthologs
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	76,797,721 bp
RNA expression pattern
	n/a
	Top expressed in
	neural layer of retina; ; trigeminal ganglion; ; seminiferous tubule; ; external carotid artery; ; spermatocyte; ; olfactory bulb; ; retinal pigment epithelium; ; spermatid; ; Rostral migratory stream; ; lumbar spinal ganglion;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleic acid binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; C-rich single-stranded DNA binding; RNA binding;
Cellular component	cytoplasm; cytosol; extracellular exosome; nucleus;
Biological process	mRNA metabolic process; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	54039
	59093
	ENSG00000183570
	ENSMUSG00000001120
	P57721
	P57722
	NM_020528; NM_001130141
	NM_021568; NM_001347216
NP_001123613; NP_065389; NP_001335167; NP_001335168; NP_001335169;
	NP_001335170; NP_001335171; NP_001335172; NP_001335173; NP_001335174; NP_001369205; NP_001369206; NP_001369207; NP_001369208; NP_001369210; NP_001369211; NP_001369212; NP_001369213; NP_001369214; NP_001369215; NP_001369216; NP_001369217; NP_001371085
	NP_001334145; NP_067543
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(rC)-binding protein 3 is a protein that in humans is encoded by the PCBP3 gene.

This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple polyadenylation sites exist for this gene.