PCK1

PCK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KHB, 1KHE, 1KHF, 1KHG, 1M51, 1NHX, 2GMV
Identifiers
Aliases	PCK1, PEPCK-C, PEPEPCKC, phosphoenolpyruvate carboxykinase 1, PCKDC
External IDs	OMIM: 614168; MGI: 97501; HomoloGene: 1944; GeneCards: PCK1; OMA:PCK1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	57,568,121 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	173,001,066 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; glomerulus; ; metanephric glomerulus; ; kidney tubule; ; human kidney; ; mucosa of colon; ; renal medulla; ; mucosa of sigmoid colon; ; mucosa of ileum;
	Top expressed in
	right kidney; ; brown adipose tissue; ; human kidney; ; left lobe of liver; ; white adipose tissue; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; intercostal muscle; ; mammary gland; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; manganese ion binding; GDP binding; phosphoenolpyruvate carboxykinase activity; GTP binding; metal ion binding; carboxylic acid binding; purine nucleotide binding; lyase activity; carboxy-lyase activity; magnesium ion binding; phosphoenolpyruvate carboxykinase (GTP) activity;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	glucose homeostasis; internal protein amino acid acetylation; lipid metabolism; response to activity; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH; oxaloacetate metabolic process; response to insulin; glyceroneogenesis; cellular response to potassium ion starvation; cellular response to retinoic acid; response to lipid; cellular response to hypoxia; cellular response to fructose stimulus; response to interleukin-6; glucose metabolic process; ageing; response to methionine; cellular response to interleukin-1; cellular response to glucagon stimulus; cellular response to cAMP; cellular response to insulin stimulus; cellular response to tumor necrosis factor; response to lipopolysaccharide; gluconeogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5105
	18534
	ENSG00000124253
	ENSMUSG00000027513
	P35558
	Q9Z2V4
	NM_002591
	NM_011044
	NP_002582
	NP_035174
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.