PCNT

PCNT
Identifiers
Aliases	PCNT, KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4, pericentrin
External IDs	OMIM: 605925; MGI: 102722; HomoloGene: 86942; GeneCards: PCNT; OMA:PCNT - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	46,445,769 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	76,278,620 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; body of tongue; ; muscle of thigh; ; thoracic diaphragm; ; Skeletal muscle tissue of rectus abdominis; ; glutes; ; triceps brachii muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; middle temporal gyrus;
	Top expressed in
	primary oocyte; ; zygote; ; interventricular septum; ; muscle of thigh; ; secondary oocyte; ; soleus muscle; ; hand; ; foot; ; extraocular muscle; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; calmodulin binding; molecular adaptor activity;
Cellular component	centriole; centrosome; centriolar satellite; microtubule; membrane; cytoskeleton; cytoplasm; microtubule organizing center; cytosol;
Biological process	positive regulation of intracellular protein transport; mitotic spindle organization; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; cilium assembly; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5116
	18541
	ENSG00000160299
	ENSMUSG00000001151
	O95613
	P48725
	NM_006031; NM_001315529
	NM_001282992; NM_008787
	NP_001302458; NP_006022
	NP_001269921; NP_032813
	Wikidata
View/Edit Human	View/Edit Mouse

Pericentrin (kendrin), also known as PCNT and pericentrin-B (PCNTB), is a protein which in humans is encoded by the PCNT gene on chromosome 21. This protein localizes to the centrosome and recruits proteins to the pericentriolar matrix (PCM) to ensure proper centrosome and mitotic spindle formation, and thus, uninterrupted cell cycle progression. This gene is implicated in many diseases and disorders, including congenital disorders such as microcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel syndrome.