PCP4

PCP4
Identifiers
Aliases	PCP4, PEP-19, Purkinje cell protein 4
External IDs	OMIM: 601629; MGI: 97509; HomoloGene: 4519; GeneCards: PCP4; OMA:PCP4 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	39,929,397 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	96,326,993 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; external globus pallidus; ; middle frontal gyrus; ; Epithelium of choroid plexus; ; putamen; ; caudate nucleus; ; nucleus accumbens; ; seminal vesicula; ; retinal pigment epithelium; ; internal globus pallidus;
	Top expressed in
	striatum of neuraxis; ; olfactory bulb; ; Cerebellum; ; layer of retina; ; neural layer of retina; ; cerebellar cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; urinary bladder; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; calcium ion binding; calmodulin binding;
Cellular component	cytosol; nucleus; protein-containing complex;
Biological process	positive regulation of neuron differentiation; calmodulin dependent kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5121
	18546
	ENSG00000183036
	ENSMUSG00000090223
	P48539
	P63054
	NM_006198
	NM_008791
	NP_006189
	NP_032817
	Wikidata
View/Edit Human	View/Edit Mouse

Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene. Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM). PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity.