PDCD1LG2

PDCD1LG2
Identifiers
Aliases	PDCD1LG2, B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2, programmed cell death 1 ligand 2
External IDs	OMIM: 605723; MGI: 1930125; HomoloGene: 10973; GeneCards: PDCD1LG2; OMA:PDCD1LG2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	5,571,282 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	29,448,561 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; testicle; ; Achilles tendon; ; appendix; ; lymph node; ; spleen; ; gallbladder; ; smooth muscle tissue; ; upper lobe of left lung; ; right lung;
	Top expressed in
	gastrula; ; embryo; ; submandibular gland; ; thymus; ; mesenteric lymph nodes; ; lumbar spinal ganglion; ; tibiofemoral joint; ; spleen; ; skin of abdomen; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular function; protein binding;
Cellular component	integral component of membrane; extracellular region; endomembrane system; membrane; plasma membrane; external side of plasma membrane; cell surface;
Biological process	negative regulation of activated T cell proliferation; T cell costimulation; negative regulation of interleukin-10 production; negative regulation of T cell proliferation; negative regulation of interferon-gamma production; immune response; positive regulation of T cell proliferation; signal transduction; cell surface receptor signaling pathway; cellular response to lipopolysaccharide; adaptive immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	80380
	58205
	ENSG00000197646
	ENSMUSG00000016498
	Q9BQ51
	Q9WUL5
	NM_025239
	NM_021396
	NP_079515
	NP_067371
	Wikidata
View/Edit Human	View/Edit Mouse

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). PDCD1LG2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response. PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1).