PDCD5

PDCD5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YYB, 2CRU, 2K6B
Identifiers
Aliases	PDCD5, TFAR19, programmed cell death 5
External IDs	OMIM: 604583; MGI: 3782009; HomoloGene: 10506; GeneCards: PDCD5; OMA:PDCD5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	32,587,453 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; body of pancreas; ; anterior pituitary; ; right auricle of heart; ; left coronary artery; ; muscle layer of sigmoid colon; ; gastric mucosa; ; apex of heart; ; anterior cingulate cortex;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; heparin binding; protein binding; acetyltransferase activator activity; beta-tubulin binding;
Cellular component	cytoplasm; extracellular exosome; nucleus; cytosol;
Biological process	cellular response to transforming growth factor beta stimulus; negative regulation of chaperone-mediated protein folding; positive regulation of release of cytochrome c from mitochondria; apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of gene expression; positive regulation of protein insertion into mitochondrial outer membrane; negative regulation of cell population proliferation; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9141
	100042424
	ENSG00000105185
	n/a
	O14737
	P56812
	NM_004708
	XM_001478256
	NP_004699
	NP_062720
	Wikidata
View/Edit Human	View/Edit Mouse

Programmed cell death protein 5 is a protein, originally identified as an apoptosis-accelerating protein, that in humans is encoded by the PDCD5 gene.

This gene encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm.

Once apoptosis is induced, the level of this protein increases and by relocation from the cytoplasm, it accumulates in the nucleus. Although its exact function is not defined, this protein is thought to play an early and universal role in apoptosis.