PDCD6

PDCD6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZN8, 2ZN9, 2ZND, 2ZNE, 2ZRS, 2ZRT, 3AAJ, 3AAK, 3WXA
Identifiers
Aliases	PDCD6, ALG-2, PEF1B, ALG2, programmed cell death 6
External IDs	OMIM: 601057; MGI: 109283; HomoloGene: 7880; GeneCards: PDCD6; OMA:PDCD6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	314,974 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	74,465,699 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; mucosa of transverse colon; ; right adrenal cortex; ; prefrontal cortex; ; left adrenal gland; ; left adrenal cortex; ; rectum; ; Brodmann area 9; ; gonad; ; anterior pituitary;
	Top expressed in
	jejunum; ; duodenum; ; ileum; ; epithelium of small intestine; ; right kidney; ; endothelial cell of lymphatic vessel; ; Epithelium of choroid plexus; ; vestibular sensory epithelium; ; endocardial cushion; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein dimerization activity; protein-membrane adaptor activity; calcium-dependent protein binding; metal ion binding; calcium-dependent cysteine-type endopeptidase activity; protein binding; identical protein binding; molecular adaptor activity; magnesium ion binding; calcium ion binding; protein homodimerization activity; protein-macromolecule adaptor activity;
Cellular component	cytoplasm; endosome; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; extracellular exosome; nucleus; Golgi membrane; COPII vesicle coat; Cul3-RING ubiquitin ligase complex; endoplasmic reticulum exit site; ER to Golgi transport vesicle membrane; cytoplasmic vesicle;
Biological process	negative regulation of protein kinase B signaling; cellular response to heat; vascular endothelial growth factor receptor-2 signaling pathway; positive regulation of endothelial cell proliferation; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of angiogenesis; positive regulation of endothelial cell migration; response to calcium ion; negative regulation of TOR signaling; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; apoptotic signaling pathway; intracellular protein transport; activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; proteolysis; endoplasmic reticulum to Golgi vesicle-mediated transport; neural crest formation; neural crest cell development; COPII vesicle coating; positive regulation of protein monoubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	10016
	18570
	ENSG00000249915
	ENSMUSG00000021576
	O75340
	P12815
	NM_001267556; NM_001267557; NM_001267558; NM_001267559; NM_013232
	NM_011051; NM_001359996
	NP_001254485; NP_001254486; NP_001254487; NP_001254488; NP_037364
	NP_035181; NP_001346925
	Wikidata
View/Edit Human	View/Edit Mouse

Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene.

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.