PDCD6IP

PDCD6IP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OEV, 2OEW, 2OEX, 2OJQ, 2R02, 2R03, 2R05, 2XS1, 2XS8, 2ZNE, 3C3O, 3C3Q, 3C3R, 3E1R, 3WUV, 4JJY
Identifiers
Aliases	PDCD6IP, AIP1, ALIX, DRIP4, HP95, programmed cell death 6 interacting protein
External IDs	OMIM: 608074; MGI: 1333753; HomoloGene: 22614; GeneCards: PDCD6IP; OMA:PDCD6IP - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	33,869,707 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	113,537,327 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; tibial nerve; ; stromal cell of endometrium; ; rectum; ; mucosa of colon; ; gastric mucosa; ; jejunal mucosa; ; skin of leg; ; monocyte; ; mucosa of sigmoid colon;
	Top expressed in
	tail of embryo; ; genital tubercle; ; lip; ; vestibular membrane of cochlear duct; ; granulocyte; ; esophagus; ; thymus; ; stroma of bone marrow; ; gastrula; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; protein dimerization activity; proteinase activated receptor binding; calcium-dependent protein binding;
Cellular component	immunological synapse; focal adhesion; microtubule organizing center; extracellular vesicle; endoplasmic reticulum exit site; extracellular region; myelin sheath; cytoskeleton; melanosome; membrane; extracellular exosome; cytoplasm; cytosol; actomyosin; bicellular tight junction; cell junction; Flemming body;
Biological process	cell cycle; mitotic metaphase plate congression; protein transport; positive regulation of exosomal secretion; viral life cycle; regulation of mitotic spindle assembly; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway; positive regulation of extracellular exosome assembly; septum digestion after cytokinesis; regulation of centrosome duplication; nucleus organization; multivesicular body assembly; regulation of extracellular exosome assembly; apoptotic process; cell division; viral budding via host ESCRT complex; viral process; actomyosin contractile ring assembly; maintenance of epithelial cell apical/basal polarity; bicellular tight junction assembly; regulation of membrane permeability; mitotic cytokinesis; viral budding; protein homooligomerization; transport; midbody abscission;
	Sources:Amigo / QuickGO
Orthologs
	10015
	18571
	ENSG00000170248
	ENSMUSG00000032504
	Q8WUM4
	Q9WU78
	NM_001162429; NM_001256192; NM_013374
	NM_001164677; NM_001164678; NM_011052
	NP_001155901; NP_001243121; NP_037506
	NP_001158149; NP_001158150; NP_035182
	Wikidata
View/Edit Human	View/Edit Mouse

Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.

This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.