PDE10A

PDE10A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OUN, 2OUP, 2OUQ, 2OUR, 2OUS, 2OUU, 2OUV, 2OUY, 2WEY, 2Y0J, 2ZMF, 3SN7, 3SNI, 3SNL, 3UI7, 3UUO, 3WI2, 3WS8, 3WS9, 3WYK, 3WYL, 3WYM, 4AEL, 4AJD, 4AJF, 4AJG, 4AJM, 4BBX, 4DDL, 4DFF, 4FCB, 4FCD, 4HEU, 4HF4, 4LKQ, 4LLJ, 4LLK, 4LLP, 4LLX, 4LM0, 4LM1, 4LM2, 4LM3, 4LM4, 4MRW, 4MRZ, 4MS0, 4MSA, 4MSC, 4MSE, 4MSH, 4MSN, 4MUW, 4MVH, 4P0N, 4P1R, 4PHW, 4TPM, 4TPP, 4WN1, 4XY2, 4YQH, 4YS7, 4ZO5, 5C1W, 5C28, 5C29, 5C2A, 5C2H, 5DH5, 5AXQ, 5DH4, 5AXP, 5C2E, 5EDH, 5EDI, 5EDG, 5EDE, 5I2R, 5B4L, 5B4K
Identifiers
Aliases	PDE10A, HSPDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC00473
External IDs	OMIM: 610652; MGI: 1345143; HomoloGene: 4852; GeneCards: PDE10A; OMA:PDE10A - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	165,988,117 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	9,205,480 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; cartilage tissue; ; left ovary; ; external globus pallidus; ; corpus epididymis; ; putamen; ; right ovary; ; anterior pituitary; ; stromal cell of endometrium; ; caudate nucleus;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; globus pallidus; ; superior frontal gyrus; ; temporal lobe; ; Amygdala; ; lobe of cerebellum; ; cerebellar vermis; ; anterior amygdaloid area; ; lateral septal nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP binding; metal ion binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; catalytic activity; phosphoric diester hydrolase activity; hydrolase activity; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytoplasm; cytosol; perikaryon; membrane; soma;
Biological process	cAMP catabolic process; regulation of protein kinase A signaling; cGMP catabolic process; regulation of cAMP-mediated signaling; metabolism; signal transduction; G protein-coupled receptor signaling pathway; negative regulation of cGMP-mediated signaling; negative regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	10846
	23984
	ENSG00000112541
	ENSMUSG00000023868
	Q9Y233
	Q8CA95
	NM_001130690; NM_006661; NM_001385079
	NM_001290707; NM_011866; NM_001347321
	NP_001124162; NP_006652
	NP_001277636; NP_001334250; NP_035996
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene.

Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.