PDE11A

PDE11A
Identifiers
Aliases	PDE11A, PPNAD2, phosphodiesterase 11A
External IDs	OMIM: 604961; MGI: 3036251; HomoloGene: 56763; GeneCards: PDE11A; OMA:PDE11A - orthologs
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	76,169,118 bp
RNA expression pattern
	Top expressed in
	deltoid muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; liver; ; gastrocnemius muscle; ; prostate; ; biceps brachii; ; right lobe of liver; ; tibialis anterior muscle; ; tibia;
	Top expressed in
	hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; ileum; ; primary visual cortex; ; midbrain tegmentum; ; jejunum; ; Cortex of frontal lobe; ; white adipose tissue; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; catalytic activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; cGMP binding;
Cellular component	cytoplasm; cytosol; cellular component;
Biological process	metabolism; signal transduction; G protein-coupled receptor signaling pathway; negative regulation of cGMP-mediated signaling; negative regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	50940
	241489
	n/a
	ENSMUSG00000075270
	Q9HCR9
	P0C1Q2
	NM_016953; NM_001077196; NM_001077197; NM_001077358
	NM_001081033
	NP_001070664; NP_001070665; NP_001070826; NP_058649
	NP_001074502
	Wikidata
View/Edit Human	View/Edit Mouse

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing's disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.