CGMP-specific phosphodiesterase type 5

PDE5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OEX, 1RKP, 1T9R, 1T9S, 1TBF, 1UDT, 1UDU, 1UHO, 1XOZ, 1XP0, 2CHM, 2H40, 2H42, 2H44, 2XSS, 3B2R, 3BJC, 3HC8, 3HDZ, 3JWQ, 3JWR, 3LFV, 3MF0, 3SHY, 3SHZ, 3SIE, 3TGE, 3TGG, 4G2W, 4G2Y, 4I9Z, 4IA0, 4MD6, 4OEW
Identifiers
Aliases	PDE5A, CGB-PDE, CN5A, PDE5, phosphodiesterase 5A
External IDs	OMIM: 603310; MGI: 2651499; HomoloGene: 842; GeneCards: PDE5A; OMA:PDE5A - orthologs
EC number	3.1.4.35
Gene location (Human)
Chr.	Chromosome 4 (human)
End	119,628,804 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	122,653,023 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; Descending thoracic aorta; ; epithelium of colon; ; tail of epididymis; ; ascending aorta; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; gastric mucosa; ; caput epididymis;
	Top expressed in
	left lung lobe; ; left colon; ; cervix; ; ciliary body; ; islet of Langerhans; ; right lung; ; ascending aorta; ; Gonadal ridge; ; ileum; ; migratory enteric neural crest cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; metal ion binding; cyclic-nucleotide phosphodiesterase activity; catalytic activity; phosphoric diester hydrolase activity; hydrolase activity; 3',5'-cyclic-GMP phosphodiesterase activity; protein binding;
Cellular component	cytosol; cellular component;
Biological process	positive regulation of MAP kinase activity; cGMP metabolic process; positive regulation of cardiac muscle hypertrophy; cGMP catabolic process; negative regulation of T cell proliferation; positive regulation of oocyte development; metabolism; relaxation of cardiac muscle; signal transduction; negative regulation of cardiac muscle contraction; regulation of nitric oxide mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	8654
	242202
	ENSG00000138735
	ENSMUSG00000053965
	O76074
	Q8CG03
	NM_033437; NM_001083; NM_033430
	NM_153422
	NP_001074; NP_236914; NP_246273
	NP_700471
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum of the clitoris and of the penis as well as the retina. It has also been recently discovered to play a vital role in the cardiovascular system.

The phosphodiesterase (PDE) isozymes, found in several tissues including the rod and cone photoreceptor cells of the retina, belong to a large family of cyclic nucleotide PDEs that catalyze cAMP and cGMP hydrolysis.

The interest in PDEs as molecular targets of drug action has grown with the development of isozyme-selective PDE inhibitors that offer potent inhibition of selected isozymes without the side-effects attributed to nonselective inhibitors such as theophylline.

Sildenafil, vardenafil, tadalafil, and avanafil are PDE5 inhibitors that are significantly more potent and selective than zaprinast and other early PDE5 inhibitors.