PDE6B

PDE6B
Identifiers
Aliases	PDE6B, CSNB3, CSNBAD2, PDEB, RP40, rd1, phosphodiesterase 6B, GMP-PDEbeta
External IDs	OMIM: 180072; MGI: 97525; HomoloGene: 237; GeneCards: PDE6B; OMA:PDE6B - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	670,782 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	108,580,263 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right uterine tube; ; right frontal lobe; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; Amygdala; ; granulocyte; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	neural layer of retina; ; retinal pigment epithelium; ; epithelium of lens; ; corneal stroma; ; ciliary body; ; iris; ; primary oocyte; ; secondary oocyte; ; embryo; ; pineal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; hydrolase activity; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	plasma membrane; photoreceptor disc membrane; photoreceptor outer segment; membrane;
Biological process	detection of light stimulus; retina development in camera-type eye; response to stimulus; visual perception; GMP metabolic process; signal transduction; phototransduction, visible light; regulation of cytosolic calcium ion concentration; regulation of rhodopsin mediated signaling pathway; G protein-coupled receptor signaling pathway; rhodopsin mediated signaling pathway; Wnt signaling pathway, calcium modulating pathway;
	Sources:Amigo / QuickGO
Orthologs
	5158
	18587
	ENSG00000133256
	ENSMUSG00000029491
	P35913
	P23440
NM_000283; NM_001145291; NM_001145292; NM_001350154; NM_001350155;
	NM_001379246; NM_001379247
	NM_008806
NP_000274; NP_001138763; NP_001138764; NP_001337083; NP_001337084;
	NP_001366175; NP_001366176
	NP_032832
	Wikidata
View/Edit Human	View/Edit Mouse

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta is the beta subunit of the protein complex PDE6 that is encoded by the PDE6B gene. PDE6 is crucial in transmission and amplification of visual signal. The existence of this beta subunit is essential for normal PDE6 functioning. Mutations in this subunit are responsible for retinal degeneration such as retinitis pigmentosa or congenital stationary night blindness.