PDE8A

PDE8A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ECM, 3ECN
Identifiers
Aliases	PDE8A, HsT19550, phosphodiesterase 8A
External IDs	OMIM: 602972; MGI: 1277116; HomoloGene: 1957; GeneCards: PDE8A; OMA:PDE8A - orthologs
EC number	3.1.4.53
Gene location (Human)
Chr.	Chromosome 15 (human)
End	85,139,145 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	80,984,281 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; middle frontal gyrus; ; inferior ganglion of vagus nerve; ; inferior olivary nucleus; ; external globus pallidus; ; subthalamic nucleus; ; mucosa of colon; ; pars reticulata; ; mucosa of sigmoid colon; ; palpebral conjunctiva;
	Top expressed in
	seminiferous tubule; ; cumulus cell; ; spermatocyte; ; lumbar subsegment of spinal cord; ; lacrimal gland; ; spermatid; ; parotid gland; ; calvaria; ; pyloric antrum; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; hydrolase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; 3',5'-cyclic-AMP phosphodiesterase activity; kinase binding; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytosol; extracellular exosome;
Biological process	cyclic nucleotide metabolic process; cAMP catabolic process; regulation of transcription, DNA-templated; signal transduction; positive regulation of protein phosphorylation; negative regulation of cell death; positive regulation of ERK1 and ERK2 cascade; cellular response to epidermal growth factor stimulus; negative regulation of hydrogen peroxide-induced cell death; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5151
	18584
	ENSG00000073417
	ENSMUSG00000025584
	O60658
	O88502
NM_001243137; NM_002605; NM_173454; NM_173455; NM_173456;
	NM_173457
	NM_008803
	NP_001230066; NP_002596; NP_775656
	NP_032829
	Wikidata
View/Edit Human	View/Edit Mouse

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene. Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.